Publications

Ref: ACS Appl. Mater. Interfaces 2024, 16, 7, 8250–8265
Description:
In this innovative study, pillar[5]arene cross-linked gelatin hydrogels were engineered as light-responsive antibiotic delivery systems. By harnessing supramolecular host–guest interactions with an azobenzene-modified antibiotic (Azo-SMX), the hydrogels achieved photo-controlled drug release upon UV irradiation. This reversible trans–cis switching triggered the selective release of active antibiotic molecules, enabling on-demand antibacterial activity against Gram-positive and Gram-negative bacteria. Supported by advanced spectroscopy, crystallography, and SEM analyses, these biocompatible, smart hydrogels showcase how supramolecular design can merge precision molecular recognition with biomedical functionality, paving the way for next-generation stimuli-responsive therapeutic materials.

Ref: Org. Lett. 2025, 27, 9, 2093–2097
Description:
In this standout study published in Organic Letters, the team introduces a pyridine-bis(carboxamide)-strapped pillar[5]arene capsule whose single-atom orientation within the macrocycle dramatically tunes guest binding. They achieved exceptionally high selectivity and affinity (Kₐ > 10⁴ M⁻¹) for 1,2-diaminoethane and other nitrile/isonitrile guests in a polar organic solvent, demonstrating the power of atomic-scale design in macrocyclic host-guest chemistry. This work sets a new benchmark for engineered molecular capsules, and opens exciting routes to tailor guest binding, adaptive materials and responsive supramolecular systems.

Ref: Chem. Commun., 2020,56, 8739-8742
Description:
A self-templated pillar[5]arene spontaneously assembles into linear supramolecular polymers through tosylate-driven host–guest interactions. This high-yield, one-step synthesis unveils dynamic, fiber-like architectures—showcasing how built-in molecular design can direct self-assembly toward smart, functional supramolecular materials.