Ref: ACS Appl. Mater. Interfaces 2024, 16, 7, 8250–8265
Description:
In this innovative study, pillar[5]arene cross-linked gelatin hydrogels were engineered as light-responsive antibiotic delivery systems. By harnessing supramolecular host–guest interactions with an azobenzene-modified antibiotic (Azo-SMX), the hydrogels achieved photo-controlled drug release upon UV irradiation. This reversible trans–cis switching triggered the selective release of active antibiotic molecules, enabling on-demand antibacterial activity against Gram-positive and Gram-negative bacteria. Supported by advanced spectroscopy, crystallography, and SEM analyses, these biocompatible, smart hydrogels showcase how supramolecular design can merge precision molecular recognition with biomedical functionality, paving the way for next-generation stimuli-responsive therapeutic materials.
