We design, synthesise and functionalise pillar[n]arene derivatives and related macrocycles to create tunable cavities and recognition sites for selective molecular encapsulation and stimulus-responsive assemblies. Our work spans new synthetic routes (including self-template and strap strategies), structural characterisation (NMR and single-crystal X-ray), and the use of subtle electronic/steric to control binding geometry and supramolecular polymer formation. Representative outputs include our pioneered synthesis of pertosylated pillar[5]arene reported in Chemical Communications and synthesis of supramolecular capsules reported in Org. Lett., presenting innovative designs of novel pillar[5]arene macrocycles and assembled materials and demonstrating both fundamental advances and routes to functional supramolecular polymers.
